Aspartate-semialdehyde dehydrogenase



Aspartate-semialdehyde dehydrogenase (ASADH) is an enzyme which is part of the biosynthesis of amino acids. It catalyzes the conversion of L-aspartate 4-semialdehyde (ASA) + phosphate + NADP to L-4-aspartyl phosphate + NADPH + H+. The images at the left and at the right correspond to one representative ASADH, i.e. the crystal structure of Aspartate-semialdehyde dehydrogenase from Vibrio cholerae (1mc4).

3D Structures of Aspartate-semialdehyde dehydrogenase
2qz9, 1mc4 – VcASADH II – Vibrio cholerae

2yv3 – ASADH – Thermus thermiphilus

1t4d, 1t4b, 1brm - EcASADH β - Escherichia coli

1pu2, 1oza - HiASADH (mutant) – Haemophilus influenzae

1nwc – HiASADH

1nwh – HiASADH reaction intermediate

ASADH binary complex
2r00 - VcASADH II + ASA

3llg – ASADH + glycerot + Pi – Mycobacterium tuberculosis

3hsk – ASADH + NADP – Candida albicans

1ys4 - ASADH + NADP – Methanocaldococcus jannaschii

1nx6 - HiASADH reaction intermediate +Pi

1ta4 - HiASADH + As

1tb4 - HiASADH + IO4

1q2x - HiASADH (mutant) + ASA

ASADH ternary complex
1pqu - HiASADH (mutant) + NADP + cacodylate + substrate analog

1pqp - HiASADH (mutant) + ASA + Pi

1gl3 - EcASADH β + NADP + substrate analog

1mb4 - VcASADH + NADP + substrate analog